London Irish, Gloucester and Saracens will all have home advantage come April when the knockout stage of the tournament kicks off.
Gloucester, who beat Ulster to top group two, will be glad to be at Kingsholm when they face Munster who continued their imperious home form by dumping reigning champions Wasps out of the tournament.
Rematch
Irish will host Perpignan who came through the same group as the Exiles as top runners up. They both recorded home wins in the pool, so a tight game at the Madejski is expected.
The final team representing the Premiership will be Saracens who finished as top seeds in group one. It will be their first appearance in the quarter-finals and they will need to beat the Ospreys if they are to progress any further.
The remaining fixture will see Cardiff travel to perennial challengers, Toulouse, who have won the competition three times.
All three Guinness teams have a strong chance of making it to the semi-finals and the prospect of another all English final is looking a firm possibility.
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